Level 1 · RCT / systematic review of RCTs
Military
RCT
Equivocal
Methodological debate
Bottom line
DoD HOPPS trial — negative primary endpoint but widely criticised for sham chamber delivering ~1.3 ATA O2 (itself potentially therapeutic).
Outcome
No difference between HBOT at 2.4 ATA and sham on primary cognitive endpoints; both arms improved.
Conditions studied
- Traumatic Brain Injury (TBI) — Multiple RCTs — Moderate evidence, UHMS review pending
Full citation
Wolf G, Cifu D, Baugh L, et al. The Effect of Hyperbaric Oxygen on Symptoms After Mild Traumatic Brain Injury (DoD HOPPS Trial). Journal of Neurotrauma. 2012. doi:10.1089/neu.2012.2549.
View on PubMed (PMID 22655971) →
Related studies
- Hyperbaric Oxygen Therapy Can Improve Post-Concussion Syndrome Years After Mild Traumatic Brain Injury (2013, Level 2)
- Hyperbaric Oxygen May Induce Angiogenesis in Patients with Prolonged Post-Concussion Syndrome (2017, Level 2)
- Hyperbaric Oxygen Therapy for Mild Traumatic Brain Injury Persistent Postconcussion Syndrome and PTSD (2017, Level 3)
- The Hyperoxic-Hypoxic Paradox (2020, Level 5)