Level 5 · Review / guideline / expert opinion
Review
Mechanism
Efrati Lab
Bottom line
The theoretical foundation Efrati Lab uses to explain HBOT efficacy across neurological, anti-aging, and tissue-regeneration indications.
Outcome
Framework explaining how intermittent hyperoxia (HBOT) mimics hypoxia at the cellular level, triggering HIF-1α stabilisation and downstream angiogenesis/stem-cell proliferation.
Conditions studied
- Traumatic Brain Injury (TBI) — Multiple RCTs — Moderate evidence, UHMS review pending
- Longevity & Anti-Aging — Early single-arm trial — Novel finding, replication pending
- Stroke Recovery — Phase 2 RCTs — Moderate evidence
Full citation
Hadanny A, Efrati S. The Hyperoxic-Hypoxic Paradox. Biomolecules. 2020. doi:10.3390/biom10060958.
View on PubMed (PMID 32183049) →
Related studies
- Hyperbaric Oxygen Therapy Can Improve Post-Concussion Syndrome Years After Mild Traumatic Brain Injury (2013, Level 2)
- Hyperbaric Oxygen May Induce Angiogenesis in Patients with Prolonged Post-Concussion Syndrome (2017, Level 2)
- Hyperbaric Oxygen Therapy for Mild Traumatic Brain Injury Persistent Postconcussion Syndrome and PTSD (2017, Level 3)
- The Effect of Hyperbaric Oxygen on Symptoms After Mild Traumatic Brain Injury (DoD HOPPS Trial) (2012, Level 1)