Level 2 · Prospective cohort / crossover
Neurological
Mechanism
Imaging
Bottom line
Mechanistic evidence that 2.0 ATA HBOT induces measurable angiogenesis in post-concussive brains.
Outcome
Perfusion MRI showed increased CBF and CBV in previously hypoperfused regions corresponding to cognitive gains.
Conditions studied
- Traumatic Brain Injury (TBI) — Multiple RCTs — Moderate evidence, UHMS review pending
- Concussion / Post-Concussion Syndrome — Mixed RCTs — Protocol-dependent
Full citation
Tal S, Hadanny A, Berkovitz N, et al. Hyperbaric Oxygen May Induce Angiogenesis in Patients with Prolonged Post-Concussion Syndrome. Restorative Neurology and Neuroscience. 2017. doi:10.3233/RNN-160714.
View on PubMed (PMID 28234660) →
Related studies
- Hyperbaric Oxygen Therapy Can Improve Post-Concussion Syndrome Years After Mild Traumatic Brain Injury (2013, Level 2)
- Hyperbaric Oxygen Therapy for Mild Traumatic Brain Injury Persistent Postconcussion Syndrome and PTSD (2017, Level 3)
- The Effect of Hyperbaric Oxygen on Symptoms After Mild Traumatic Brain Injury (DoD HOPPS Trial) (2012, Level 1)
- The Hyperoxic-Hypoxic Paradox (2020, Level 5)