Level 2 · Prospective cohort / crossover
Neurological
Efrati Lab
Crossover
Bottom line
Early Efrati Lab paper establishing HBOT benefit in chronic post-concussion syndrome using crossover design (patients as own controls).
Outcome
Significant cognitive gains + SPECT-verified improved cerebral blood flow in chronic mTBI patients 1–6 years post-injury.
Conditions studied
- Traumatic Brain Injury (TBI) — Multiple RCTs — Moderate evidence, UHMS review pending
- Concussion / Post-Concussion Syndrome — Mixed RCTs — Protocol-dependent
Full citation
Boussi-Gross R, Golan H, Fishlev G, et al. Hyperbaric Oxygen Therapy Can Improve Post-Concussion Syndrome Years After Mild Traumatic Brain Injury. PLOS ONE. 2013. doi:10.1371/journal.pone.0079995.
View on PubMed (PMID 23441039) →
Related studies
- Hyperbaric Oxygen May Induce Angiogenesis in Patients with Prolonged Post-Concussion Syndrome (2017, Level 2)
- Hyperbaric Oxygen Therapy for Mild Traumatic Brain Injury Persistent Postconcussion Syndrome and PTSD (2017, Level 3)
- The Effect of Hyperbaric Oxygen on Symptoms After Mild Traumatic Brain Injury (DoD HOPPS Trial) (2012, Level 1)
- The Hyperoxic-Hypoxic Paradox (2020, Level 5)