Level 5 · Review / guideline / expert opinion
Review
Mechanism
Bottom line
Still the most-cited single mechanism reference. Essential reading for understanding HBOT biology.
Outcome
Comprehensive synthesis of HBOT biochemical mechanisms: NO signalling, stem-cell mobilisation, HIF-1α, antimicrobial action.
Conditions studied
- Diabetic Wound Healing — Strong (Level 1A) — UHMS approved
- Radiation Tissue Injury — Strong — UHMS approved, Marx protocol validated
- Traumatic Brain Injury (TBI) — Multiple RCTs — Moderate evidence, UHMS review pending
Full citation
Thom SR. Hyperbaric Oxygen: Its Mechanisms and Efficacy. Plastic and Reconstructive Surgery. 2011. doi:10.1097/PRS.0b013e3181fbe2bf.
View on PubMed (PMID 21200283) →
Related studies
- Hyperbaric Oxygen Therapy Facilitates Healing of Chronic Foot Ulcers in Patients with Diabetes (2010, Level 1)
- Lack of Effectiveness of Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcer (2013, Level 3)
- Prevention of Osteoradionecrosis: A Randomized Prospective Clinical Trial of Hyperbaric Oxygen Versus Penicillin (1985, Level 1)
- Hyperbaric Oxygen Therapy for Late Radiation Tissue Injury (Cochrane Review) (2016, Level 1)