Level 1 · RCT / systematic review of RCTs
UHMS-approved
Meta-analysis
Cochrane
Bottom line
Current Cochrane synthesis supporting UHMS-approved use of HBOT for soft-tissue radionecrosis and osteoradionecrosis.
Outcome
HBOT improves outcomes in late radiation tissue injury of the head/neck and bowel; evidence for other sites remains limited.
Conditions studied
- Radiation Tissue Injury — Strong — UHMS approved, Marx protocol validated
Full citation
Bennett MH, Feldmeier J, Hampson NB, et al. Hyperbaric Oxygen Therapy for Late Radiation Tissue Injury (Cochrane Review). Cochrane Database of Systematic Reviews. 2016. doi:10.1002/14651858.CD005005.pub4.
View on PubMed (PMID 27123955) →
Related studies
- Prevention of Osteoradionecrosis: A Randomized Prospective Clinical Trial of Hyperbaric Oxygen Versus Penicillin (1985, Level 1)
- Tenth European Consensus Conference on Hyperbaric Medicine (ECHM) (2017, Level 5)
- Hyperbaric Oxygen Therapy Indications, 15th Edition (UHMS) (2023, Level 5)
- Hyperbaric Oxygen: Its Mechanisms and Efficacy (2011, Level 5)