Level 1 · RCT / systematic review of RCTs
UHMS-approved
Prevention
RCT
Bottom line
Classic trial establishing the Marx protocol — 20/10 pre- and post-operative HBOT for prevention of osteoradionecrosis after dental extraction in irradiated jaws.
Outcome
ORN rate: 5.4% HBOT (20 pre-op + 10 post-op sessions) vs 29.9% penicillin group.
Conditions studied
- Radiation Tissue Injury — Strong — UHMS approved, Marx protocol validated
Full citation
Marx RE, Johnson RP, Kline SN. Prevention of Osteoradionecrosis: A Randomized Prospective Clinical Trial of Hyperbaric Oxygen Versus Penicillin. Journal of the American Dental Association. 1985. doi:10.14219/jada.archive.1985.0163.
View on PubMed (PMID 3882848) →
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- Hyperbaric Oxygen: Its Mechanisms and Efficacy (2011, Level 5)