Level 3 · Retrospective cohort / observational
Wound
Observational
Equivocal
Bottom line
Real-world registry study challenging HBOT effectiveness outside strict Wagner 3+ selection — reinforces that patient selection matters.
Outcome
No difference in healing or amputation at 1 year between HBOT and non-HBOT cohorts in a large registry population.
Conditions studied
- Diabetic Wound Healing — Strong (Level 1A) — UHMS approved
Full citation
Margolis DJ, Gupta J, Hoffstad O, et al. Lack of Effectiveness of Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcer. Diabetes Care. 2013. doi:10.2337/dc12-2160.
View on PubMed (PMID 23835691) →
Related studies
- Hyperbaric Oxygen Therapy Facilitates Healing of Chronic Foot Ulcers in Patients with Diabetes (2010, Level 1)
- Tenth European Consensus Conference on Hyperbaric Medicine (ECHM) (2017, Level 5)
- Hyperbaric Oxygen Therapy Indications, 15th Edition (UHMS) (2023, Level 5)
- Hyperbaric Oxygen: Its Mechanisms and Efficacy (2011, Level 5)