Level 1 · RCT / systematic review of RCTs
Military
RCT
Equivocal
Bottom line
DoD-funded negative trial. Compare with Harch 2017 — methodological debate over sham-chamber pressure confound continues.
Outcome
No HBOT-vs-sham difference on primary endpoints; both arms improved — placebo/attention effect debated.
Conditions studied
- Post-Traumatic Stress Disorder (PTSD) — Early-phase trials — Limited evidence
- Traumatic Brain Injury (TBI) — Multiple RCTs — Moderate evidence, UHMS review pending
Full citation
Cifu DX, Hart BB, West SL, et al. The Effect of HBOT on Postconcussion Symptoms in Persons with Combat-Related mTBI (BRIMS Trial). Journal of Head Trauma Rehabilitation. 2014. doi:10.1097/HTR.0b013e3182a6aaf0.
View on PubMed (PMID 24052094) →
Related studies
- Hyperbaric Oxygen Therapy Can Improve Post-Concussion Syndrome Years After Mild Traumatic Brain Injury (2013, Level 2)
- Hyperbaric Oxygen May Induce Angiogenesis in Patients with Prolonged Post-Concussion Syndrome (2017, Level 2)
- Hyperbaric Oxygen Therapy for Mild Traumatic Brain Injury Persistent Postconcussion Syndrome and PTSD (2017, Level 3)
- The Effect of Hyperbaric Oxygen on Symptoms After Mild Traumatic Brain Injury (DoD HOPPS Trial) (2012, Level 1)