Level 1 · RCT / systematic review of RCTs
UHMS-approved
Emergency
RCT
Bottom line
Pivotal RCT establishing 3-session HBOT protocol as standard of care for serious CO poisoning. Weaver protocol remains the referenced treatment schedule.
Outcome
HBOT at 3.0 ATA reduced cognitive sequelae at 6 weeks (25% vs 46%) and 12 months (18% vs 33%) vs normobaric O2.
Conditions studied
- Carbon Monoxide Poisoning — Strong (RCT) — UHMS approved
Full citation
Weaver LK, Hopkins RO, Chan KJ, et al. Hyperbaric Oxygen for Acute Carbon Monoxide Poisoning. New England Journal of Medicine. 2002. doi:10.1056/NEJMoa013121.
View on PubMed (PMID 12379782) →
Related studies
- Tenth European Consensus Conference on Hyperbaric Medicine (ECHM) (2017, Level 5)
- Hyperbaric Oxygen Therapy Indications, 15th Edition (UHMS) (2023, Level 5)
- Long-Term Outcomes from Hyperbaric Oxygen for Acute CO Poisoning (2014, Level 2)